Hydrops fetalis d/t Hb ba is associated with?
Correct Answer: Hb ba's cannot release oxygen to fetal tissues
Description: - Hydrops fetalis is seen in most severe form of a-thalassemia, caused by deletion of all four a-globin genes. - Hb in these fetus have tetramers of g-globin chains (hemoglobin Bas) which have high affinity for oxygen. - This results in decreased delivery of oxygen to the tissues. - Survival in early development of these fetus is d/t expression of z chains, an embryonic globin that pairs with g chains to form functional z 2 g 2 Hb tetramer.
Category:
Pathology
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