**Core Concept**
The question tests the understanding of **hormone classification** based on their solubility and mechanism of action, specifically distinguishing between **hydrophilic** and **lipophilic hormones**. Hydrophilic hormones act through **cell surface receptors**, while lipophilic hormones act on **nuclear receptors**.

**Why the Correct Answer is Right**
Lipophilic hormones, such as **steroid** and **thyroid hormones**, can diffuse through the cell membrane and act on **nuclear receptors**, directly influencing gene transcription. This is in contrast to hydrophilic hormones, like **peptide hormones**, which cannot diffuse through the cell membrane and instead bind to **cell surface receptors**, triggering a signaling cascade.

**Why Each Wrong Option is Incorrect**
**Option A:** This would be incorrect because it is not specified, but typically, hydrophilic hormones are being considered in such a context.
**Option B:** Similarly, without specifics, we can't directly address why it's incorrect, but the question format implies it's one of the hydrophilic hormones.
**Option C:** Again, lacking specifics, but the implication is it's among the hydrophilic group, not the lipophilic one being sought.
**Option D:** This option is not directly addressed due to the lack of specifics in the query.

**Clinical Pearl / High-Yield Fact**
Remember, **steroid hormones** are classic examples of lipophilic hormones that act on nuclear receptors, influencing gene expression directly. This mechanism underlies their role in various physiological and pathological processes.

**Correct Answer:** Correct Answer: D.