Which of the following Human papilloma virus subtypes are not covered by Quadrivalent Anti- cervical cancer vaccine?
**Core Concept:** Human papillomavirus (HPV) is a group of over 200 related viruses, some of which can cause genital warts and various types of cancer, including cervical cancer. The Quadrivalent Anti-cervical cancer vaccine targets high-risk HPV types involved in cervical cancer development.
**Why the Correct Answer is Right:** The Quadrivalent vaccine (Gardasil) protects against four high-risk HPV types: HPV 16, 18, 45, and 31. These types are known to cause the majority of cervical cancers.
**Why Each Wrong Option is Incorrect:**
A. HPV 6 and 11: These are low-risk types responsible for causing genital warts but not cervical cancer.
B. HPV 52 and 58: These are high-risk types involved in cervical cancer development but are included in the Quadrivalent vaccine.
C. HPV 42: This is a high-risk type that is not covered by the Quadrivalent vaccine.
D. HPV 56: This is a high-risk type involved in cervical cancer development but is included in the Quadrivalent vaccine.
**Clinical Pearl:** The HPV vaccine is essential preventive measure against cervical cancer, as it targets high-risk HPV types responsible for over 70% of cervical cancer cases. However, it does not protect against all HPV types or prevent genital warts caused by low-risk types.
**Correct Answer:** D. HPV 56
**Explanation:** The Quadrivalent vaccine (Gardasil) covers HPV types 16, 18, 45, and 31, which are responsible for most cervical cancers. HPV 56 is a high-risk type involved in cervical cancer development but is included in the Quadrivalent vaccine, making it the correct answer.