Human papilloma virus-8 infection is associated with:March 2012
## **Core Concept**
Human papillomavirus (HPV) is a group of viruses that can cause infections in humans. There are more than 100 types of HPV, some of which are associated with cancer, while others cause non-cancerous conditions like warts. HPV-8, along with HPV-5, is notably linked to a specific skin condition.
## **Why the Correct Answer is Right**
HPV-8, along with HPV-5, is associated with **epidermodysplasia verruciformis (EV)**, a rare skin disorder characterized by an abnormal susceptibility to HPV infections, particularly types 5 and 8. This condition increases the risk of skin cancer. The viruses in this context exploit the host's immune response and can lead to both benign and malignant skin lesions.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because while HPV types can be associated with various conditions, HPV-8's notable association is not with common warts or the other listed conditions primarily.
- **Option B:** This option is incorrect as there's no well-established direct link between HPV-8 and the conditions listed here as there is with epidermodysplasia verruciformis.
- **Option C:** This option might seem plausible due to the association of some HPV types with cervical cancer, but HPV-8 is specifically noted for its link to epidermodysplasia verruciformis, not cervical cancer.
- **Option D:** This option is a distractor and does not relate to the known associations of HPV-8.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that **epidermodysplasia verruciformis** is a rare condition but is notably associated with HPV types 5 and 8. This condition can progress to skin cancer, making the identification of HPV types and their associations clinically significant.
## **Correct Answer:** D. Epidermodysplasia verruciformis.