ENT Human immunodeficiency virus (HIV) affects the immune response. The primary change brought about is: A A gammaglobulinemia B Defect in cell-mediated immunity C Defect in complement system D Defect in natural killer cells 💡 Explanation Human immunodeficiency virus (HIV) affects the immune response. The primary change brought about is: ✓ Correct Answer: B. Defect in cell-mediated immunity