How will you decrease aminoglycoside toxicity?
Correct Answer: Total dose OD
Description: Ans. is 'a' i.e., High dose OD Authoities recommend giving a single total daily dose regime for aminoglycosides for patients with normal renal function. This is based on the following considerations: 1) Aminoglycosides exe concentration dependent bactericidal action and a long post antibiotic effect, therefore higher plasma concentrations attained after the single daily dose will be equally or more effective than the divided doses. 2) With the single daily dose the plasma concentration will remain subthreshold for ototoxicity and nephrotoxicity for a longer period each day allowing washout of the drug from the endolymph and renal coex, thus decreasing the toxic effects.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now