Physiology How does the distal nephron differ functionally from the proximal tubule? A The distal nephron has a more negative intraluminal potential than the proximal tubule. B The distal nephron is less responsive to aldosterone than the proximal tubule. C The distal nephron is more permeable to hydrogen ion than the proximal tubule. D The distal nephron secretes more hydrogen ion than the proximal tubule does. 💡 Explanation How does the distal nephron differ functionally from the proximal tubule? ✓ Correct Answer: A. The distal nephron has a more negative intraluminal potential than the proximal tubule.