Hormone replacement therapy is not
Correct Answer: Prevention of CAD
Description: Answer- D (Prevention CAD)Hormone replacement therapy increases the risk of MI (coronary aery disease). The increased risk is attributed to progestin component.o H restore Ca++ balance, fuher bone loss is prevented and the excess fracture risk is nullified. o There is a higher incidence of breast cancer.o Risk for endometrial carcinoma is not increased as protective effect of progestin nullify the carcinogenic effect of estrogen.o There is increased risk for gall stone and migraine.o There is a small protective effective of H on colorectal cancer.Note :?o Usually in H combination of estrogen and progestin is given (combined H), except in hysterectimized women where estrogen alone is given.o With estrogen alone there is increased risk of endometrial cancer and decrease risk of coronary aery disease (as estrogen increases HDL and decreases LDL and triglyceride level).o So for H with estrogen alone the answer of this question will change. In that case it will be option 'a' i.e., increased risk of coronary aery disease.
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Gynaecology & Obstetrics
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