Hormonal therapy is useful if Cancer breast expresses …
**Core Concept**
Hormonal therapy in breast cancer targets specific receptors to inhibit cancer growth. The primary receptors of interest are **estrogen receptors (ER)** and **progesterone receptors (PR)**. Breast cancer cells that express these receptors are more likely to respond to hormonal therapy.
**Why the Correct Answer is Right**
The correct answer is related to the expression of hormone receptors in breast cancer cells. **Estrogen receptor (ER) positivity** is a key factor in determining the suitability of hormonal therapy. Drugs such as tamoxifen and aromatase inhibitors can block the effects of estrogen on cancer cells, reducing tumor growth.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it is not directly related to the primary target of hormonal therapy in breast cancer.
**Option C:** Similarly, this option is not relevant to the main mechanism of hormonal therapy.
**Option D:** This option does not accurately describe the primary receptor targeted by hormonal therapy in breast cancer.
**Clinical Pearl / High-Yield Fact**
A crucial point to remember is that **hormone receptor-positive breast cancers** tend to have a better prognosis and are more likely to respond to hormonal therapy.
**Correct Answer:** D. ER/PR positivity