**Core Concept**
Non-Hodgkin's lymphoma (NHL) is a heterogeneous group of lymphoid malignancies characterized by the uncontrolled proliferation of lymphoid cells. Unlike Hodgkin's lymphoma, NHL exhibits a wide range of histological and clinical features.

**Why the Correct Answer is Right**
The correct option will be a characteristic feature that is not typically associated with non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma often presents with systemic symptoms such as fever, weight loss, and night sweats, and may exhibit lymphadenopathy, splenomegaly, and hepatomegaly. In addition, NHL may involve extranodal sites, such as the gastrointestinal tract, skin, and central nervous system.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option might be a characteristic feature of non-Hodgkin's lymphoma, such as lymphadenopathy or splenomegaly.
* **Option B:** This option might also be a characteristic feature of non-Hodgkin's lymphoma, such as systemic symptoms or extranodal involvement.
* **Option C:** This option might be a characteristic feature of Hodgkin's lymphoma, such as the presence of Reed-Sternberg cells.

**Clinical Pearl / High-Yield Fact**
A key distinction between non-Hodgkin's lymphoma and Hodgkin's lymphoma is the presence of Reed-Sternberg cells, which are typically seen in Hodgkin's lymphoma.

**Correct Answer:** C.