**Core Concept**
Wilson's disease is an autosomal recessive disorder characterized by excessive accumulation of copper in the body, particularly in the liver, brain, and other organs. This accumulation leads to histopathological changes that can be observed in various tissues.

**Why the Correct Answer is Right**
The histopathological changes in Wilson's disease are primarily due to the accumulation of copper in the cells, leading to liver damage and necrosis. The liver biopsy typically shows **periportal and pericentral necrosis of hepatocytes**, **megalocytosis**, and **fatty change**. Additionally, there may be **pseudolaminar necrosis** in the liver, which is a characteristic feature of Wilson's disease.

**Why Each Wrong Option is Incorrect**
**Option A:** This option does not accurately describe the histopathological changes in Wilson's disease. While liver damage is a key feature, the specific changes mentioned do not typically occur in Wilson's disease.

**Option B:** This option is incorrect as it does not accurately describe the histopathological changes in Wilson's disease. Wilson's disease does not typically cause granulomatous inflammation.

**Option C:** This option is incorrect as it does not accurately describe the histopathological changes in Wilson's disease. Wilson's disease does not typically cause calcification of the liver.

**Clinical Pearl / High-Yield Fact**
Wilson's disease can be diagnosed by demonstrating low serum ceruloplasmin levels, high urinary copper excretion, and characteristic histopathological changes in the liver.

**Correct Answer: C.**