**Question:** Finding on histopathological examination in the liver in case of malaria is -

A. Hepatocellular necrosis
B. Mononuclear cell infiltration
C. Portal tract inflammation
D. Cholestasis

**Core Concept:** Malaria is a parasitic infection caused by Plasmodium species, primarily affecting humans. The liver plays a crucial role in malaria infection as Plasmodium parasites undergo asexual reproduction in the liver before causing symptoms in other organs.

**Why the Correct Answer is Right:**

In malaria, the liver is the primary target organ for the Plasmodium parasite. The parasite invades hepatocytes (liver cells), where it undergoes schizogony, a process of asexual reproduction. This results in hepatocellular damage, leading to hepatocellular necrosis (cell death).

**Why Each Wrong Option is Incorrect:**

A. Hepatocellular necrosis is the correct finding in malaria, so this option is not valid.
B. Mononuclear cell infiltration refers to the influx of white blood cells into tissues, but it is not the primary finding in malaria liver pathology.
C. Portal tract inflammation is a general term for inflammation in the liver's portal triad, which includes the hepatic artery, bile duct, and portal vein. In malaria, hepatocellular necrosis is the primary finding, not portal tract inflammation.
D. Cholestasis is a condition characterized by impaired bile flow from the liver. In malaria, hepatocellular necrosis is the primary finding, not cholestasis.

**Clinical Pearl:**

Understanding the role of the liver in malaria and the associated histopathological findings is crucial for diagnosing the disease and ruling out other liver diseases. A comprehensive understanding of liver pathology in malaria allows medical professionals to diagnose, manage, and prevent complications effectively.