Finding on histopathological examination in liver in case of malaria is :
**Core Concept**
Malaria is a protozoal infection caused by Plasmodium species, which primarily affects the erythrocytes and the liver. Histopathological examination of the liver in malaria reveals specific changes due to the sequestration of infected erythrocytes and the host's immune response. The liver's reticuloendothelial system, particularly the Kupffer cells, plays a crucial role in this process.
**Why the Correct Answer is Right**
In malaria, the infected erythrocytes are sequestered in the liver sinusoids, where they are phagocytosed by the Kupffer cells. This leads to the hyperplasia of Kupffer cells, which are then filled with the pigment-laden macrophages. The periportal area is predominantly affected due to the accumulation of infected erythrocytes and the subsequent activation of the immune response. The pigments, such as hemozoin, are derived from the breakdown of hemoglobin by the Plasmodium species.
**Why Each Wrong Option is Incorrect**
**Option A:** Microabscess formation is not a characteristic finding in malaria. Microabscesses are typically associated with bacterial infections, such as those caused by Staphylococcus aureus or Pseudomonas aeruginosa.
**Option C:** Non-caseating granuloma is a finding associated with chronic infections, such as tuberculosis or sarcoidosis. It is not a characteristic feature of malaria.
**Option D:** Non-specific finding of neutrophilic infiltration is not a typical histopathological finding in malaria. Neutrophils are more commonly associated with acute bacterial infections.
**Clinical Pearl / High-Yield Fact**
Kupffer cell hyperplasia with pigment-laden macrophages is a distinctive feature of malaria on histopathological examination. This finding can aid in the diagnosis of malaria, particularly in cases where the clinical presentation is atypical.
**✓ Correct Answer: B. Kupffer's cell hyperplasia with macrophage infiltration around periportal area laden with pigments.**