**Core Concept**
Histones are the chief protein components of chromatin, a complex of DNA and protein that makes up chromosomes. The nucleosome core is the basic unit of chromatin, consisting of a segment of DNA wrapped around a core of histone proteins. There are five types of histones, known as H1, H2A, H2B, H3, and H4.
**Why the Correct Answer is Right**
Histones H2A, H2B, H3, and H4 form the core of the nucleosome, which is the basic unit of chromatin. These histones are responsible for the wrapping of DNA around the nucleosome core, thereby packaging the DNA into a more compact structure. The histone H1, also known as the linker histone, binds to the linker DNA between nucleosomes, further compacting the chromatin.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because H2A, H2B, H3, and H4 are the core histones in the nucleosome.
**Option B:** Incorrect because H2A, H2B, H3, and H4 are the core histones in the nucleosome.
**Option C:** Incorrect because H2A, H2B, H3, and H4 are the core histones in the nucleosome.
**Option D:** This option is missing, but if you provide the options, I can complete the explanation.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that histone modifications, such as acetylation and methylation, play a crucial role in regulating gene expression by altering chromatin structure.
**Correct Answer: A. H1**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.