The histology of Lobular carcinoma of breast reveals-
**Core Concept**
Lobular carcinoma of the breast is a type of invasive breast cancer characterized by the presence of malignant cells in the lobules of the breast. The histology of lobular carcinoma is distinct from that of ductal carcinoma, with a unique pattern of tumor cell growth and invasion.
**Why the Correct Answer is Right**
The histology of lobular carcinoma is typically characterized by a single-file or "Indian file" pattern of tumor cells in the stroma, with a loss of the normal lobular architecture. This pattern is due to the invasive nature of the tumor cells, which proliferate and grow in a linear fashion. The tumor cells often have a characteristic "signet-ring" appearance, with a small amount of amphiphilic cytoplasm and a large, pale nucleus. This unique histological pattern is a hallmark of lobular carcinoma and is often used for diagnosis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the histology of lobular carcinoma. While some breast cancers may exhibit a "single-file" pattern, this is not a characteristic feature of lobular carcinoma.
**Option B:** This option is incorrect because it describes the histology of a different type of breast cancer, such as ductal carcinoma in situ (DCIS).
**Option C:** This option is incorrect because it describes a feature of lobular carcinoma in situ (LCIS), a benign condition that is often associated with an increased risk of developing invasive breast cancer.
**Clinical Pearl / High-Yield Fact**
To remember the histological features of lobular carcinoma, recall the "single-file" pattern of tumor cells in the stroma, which is a hallmark of this type of breast cancer.
**Correct Answer: C.**