**Core Concept**
Hashimoto thyroiditis is a form of autoimmune thyroiditis characterized by lymphocytic infiltration and destruction of thyroid follicles, leading to hypothyroidism. The histological features of this condition are crucial for its diagnosis.

**Why the Correct Answer is Right**
Hashimoto thyroiditis typically shows lymphocytic infiltration of the thyroid gland, with a predominance of CD4+ T cells and CD20+ B cells. The lymphocytes surround and destroy the thyroid follicles, leading to a decrease in thyroid hormone production. The presence of Hürthle cells, which are large, eosinophilic cells with abundant cytoplasm and a large nucleus, is also a characteristic feature of Hashimoto thyroiditis.

**Why Each Wrong Option is Incorrect**
**Option A:** The presence of germinal centers is a characteristic feature of Hashimoto thyroiditis, where B cells proliferate and differentiate into plasma cells, producing autoantibodies against thyroid antigens.
**Option B:** The formation of lymphoid follicles with a germinal center is indeed a feature of Hashimoto thyroiditis, where B cells undergo somatic hypermutation and class switching.
**Option C:** The presence of colloid-filled thyroid follicles is not a characteristic feature of Hashimoto thyroiditis, as the condition is characterized by lymphocytic infiltration and destruction of the thyroid follicles.

**Clinical Pearl / High-Yield Fact**
Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas, and it is more common in women than in men.

**Correct Answer:** C.