**Core Concept**
Hirsutism is a condition characterized by excessive hair growth in females, often due to an excess of androgens such as testosterone. Various medications can cause hirsutism as a side effect, often due to their androgenic or anti-androgenic properties.

**Why the Correct Answer is Right**
Hirsutism can be caused by medications that either increase androgen levels or have anti-androgenic effects. Drugs like minoxidil, testosterone, and anabolic steroids increase androgen levels, leading to hirsutism. On the other hand, drugs like spironolactone and flutamide have anti-androgenic effects, which can also cause hirsutism.

**Why Each Wrong Option is Incorrect**
**Option A:**
* Incorrect because minoxidil is known to cause hirsutism by increasing androgen levels.

**Option B:**
* Incorrect because anabolic steroids have androgenic effects, leading to hirsutism.

**Option C:**
* Incorrect because spironolactone has anti-androgenic effects, which can cause hirsutism.

**Clinical Pearl / High-Yield Fact**
Spironolactone, an anti-androgen medication, can cause gynecomastia (breast tissue growth in males) and hirsutism in females due to its anti-androgenic effects.

**Correct Answer:** D