**Question:** Hirschprung's disease is treated by

A. Neostigmine
B. Botulinum toxin
C. Surgery
D. Botulinum toxin

**Correct Answer:** C. Surgery

**Core Concept:** Hirschprung's disease is a congenital disorder characterized by the absence of functional smooth muscle cells in the distal part of the colon. This leads to impaired peristalsis and constipation.

**Why the Correct Answer is Right:** The correct answer, surgery, is because it addresses the underlying problem of absent or dysfunctional smooth muscle cells in Hirschprung's disease. In this case, the surgical procedure, called a pull-through procedure, involves creating a new continuity between the rectum and the distal colon, allowing for normal bowel movements.

**Why Each Wrong Option is Incorrect:**

A. Neostigmine (anticholinesterase) is indicated for the treatment of myasthenia gravis and is not related to treating Hirschprung's disease.
B. Botulinum toxin (neurotoxin) is used for botulinum poisoning and spastic conditions, but not for treating Hirschprong's disease.
D. Botulinum toxin (neurotoxin) is used for spastic conditions, not for treating Hirschprong's disease.

**Clinical Pearl:** The management of Hirschprong's disease requires a thorough understanding of the disease mechanism and the surgical intervention to address it effectively. This knowledge is crucial for treating patients with this condition and ensuring their optimal recovery.