Okay, let's tackle this question about Hirschprung's disease. First, I need to recall what I know about this condition. Hirschprung's is a congenital disorder where nerve cells in the colon don't develop properly, leading to a blockage in the large intestine. The key thing here is that there's an absence of ganglion cells in the myenteric and submucosal plexuses of the affected bowel segment.

The correct answer options would typically include the classic presentation: neonatal failure to pass meconium, which is a red flag. Also, there's a family history possibility since it can have a genetic component. The pathophysiology involves the aganglionosis in the distal colon, usually affecting the rectosigmoid region. Diagnosis is confirmed by rectal biopsy showing the absence of ganglion cells and the presence of hypertrophied nerve trunks. Treatment is surgical, like the Soave procedure.

Now, the user provided the question but didn't list the options. Without the options, I need to infer possible distractors. Common incorrect options might include things like it's an acquired condition (which it's not), or that it's associated with Hirschsprung's disease (a similar name but different condition). Another wrong option could be that it's caused by a deficiency in acetylcholinesterase, which is involved in other neuromuscular disorders but not Hirschprung's.

For the clinical pearl, it's important to remember that the key diagnostic feature is the absence of ganglion cells and the presence of hypertrophied nerve fibers in the biopsy. Also, the association with Down syndrome increases the risk, so that's a high-yield fact.

I need to structure the explanation with the required sections. Core concept is the aganglionosis in the colon. The correct answer explanation would detail the pathophysiology and clinical features. Then, each wrong option is addressed. The clinical pearl should highlight the biopsy findings and Down syndrome association. Finally, the correct answer line.

I have to make sure each section is concise, uses medical terminology, and stays within the character limit. Also, avoid markdown except for bold labels. Let me check if I missed any key points. Maybe mention that the disease can present later in life with chronic constipation, but the neonatal presentation is more classic. Also, the surgical treatment options. Need to ensure that the explanation is thorough but not too lengthy.

**Core Concept**
Hirschprung’s disease is a congenital aganglionic megacolon caused by the absence of ganglion cells in the myenteric and submucosal plexuses of the distal colon, leading to functional obstruction. It is diagnosed via rectal biopsy showing **hypertrophied, disorganized nerve trunks** and **absent ganglion cells**.

**Why the Correct Answer is Right**
The hallmark of Hirschprung’s disease is **aganglionosis** in the affected bowel segment, typically the rectosigmoid region. This results in uncoordinated peristalsis and proximal bowel dilation. Diagnosis is confirmed by **rectal suction biopsy**, which reveals the absence of Meissner’s and Auerbach’s plexus ganglion cells and the presence of **hyperplastic submucosal ganglion cell-free nerve trunks**. Clinical features include neonatal failure to pass meconium, chronic const

✓ Correct Answer: A. Sometimes found in adult