Little or no changes are seen on light microscopy in this syndrome. The disease is most common in children. Spontaneous remission is common in children and is enhanced by steroid therapy. Over 95% of children achieve remission within 8 weeks of institution of prednisone therapy. Therefore, in children with nephrotic syndrome, empiric therapy is frequently employed, rather than initial renal biopsy. Only 50% of adults will remit, and thus biopsy is more frequently required. Relapse is common in both children and adults.