Gynaecology & Obstetrics High levels of maternal serum alpha-fetoprotein seen in all of the following, EXCEPT. A Cardiac anomaly B Skeletal deformity C Trisomy 21 D Neural tube defect 💡 Explanation High levels of maternal serum alpha-fetoprotein seen in all of the following, EXCEPT. ✓ Correct Answer: C. Trisomy 21