**Core Concept**
Herpes simplex virus (HSV) is a double-stranded DNA virus belonging to the family Herpesviridae, which causes recurrent and chronic infections in humans. HSV infects the nervous system and leads to the production of viral particles that remain dormant in the host's neurons.

**Why the Correct Answer is Right**
HSV is a DNA virus that enters the host through skin or mucous membranes, where it infects nerve cells and travels to the central nervous system. The virus then replicates within the cell and forms new viral particles, which are released into the bloodstream and cause local lesions. The virus also establishes a latent infection in the host's neurons, where it remains dormant until reactivated by stress, trauma, or other stimuli.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because HSV is not a RNA virus; it is a DNA virus.
**Option B:** Incorrect because HSV does not cause a systemic infection that affects multiple organ systems; it is primarily an infection of the skin and nervous system.
**Option C:** Incorrect because HSV is not a bacterium; it is a virus.

**Clinical Pearl / High-Yield Fact**
HSV can be transmitted from mother to child during childbirth, leading to neonatal herpes, a serious and potentially life-threatening infection.

**Correct Answer: C. Herpes simplex virus is a DNA virus.**