Microbiology Most sensitive test for the diagnosis of herpes simplex (HSV) encephalitis is? A Cerebrospinal fluid (CSF) protein analysis B HSV culture C HSV IgG antibody D HSV polymerase chain reaction 💡 Explanation Most sensitive test for the diagnosis of herpes simplex (HSV) encephalitis is? ✓ Correct Answer: D. HSV polymerase chain reaction