**Core Concept**
Poliovirus is an enterovirus that primarily affects the gastrointestinal tract, but it is also known for its ability to spread through the bloodstream (hermatogenous route) and along the neural pathways (neural route), leading to various clinical manifestations.

**Why the Correct Answer is Right**
Poliovirus enters the body through the oral route and multiplies in the gastrointestinal tract. From there, it can spread to other parts of the body through the bloodstream, causing hermatogenous spread. Additionally, poliovirus can also infect and replicate within the neurons of the central nervous system, leading to neural spread and potential neurological complications, such as paralysis. This unique ability to spread through both hermatogenous and neural routes is characteristic of poliovirus.

**Why Each Wrong Option is Incorrect**
**Option A:** Rabies virus primarily spreads through the neural route, but it does not have a significant hermatogenous spread. It is a lyssavirus that infects the central nervous system and is transmitted through the saliva of infected animals.
**Option B:** Varicella zoster virus spreads through the hermatogenous route, but it does not have a significant neural spread. It is a herpesvirus that primarily causes chickenpox and shingles, and its spread is mainly through the bloodstream.
**Option D:** E.B. Virus (Epstein-Barr virus) is a herpesvirus that spreads through the hermatogenous route, but it does not have a significant neural spread. It is the causative agent of infectious mononucleosis and is transmitted through saliva and other bodily fluids.

**Clinical Pearl / High-Yield Fact**
Poliovirus can cause a range of clinical manifestations, including asymptomatic infection, minor gastrointestinal symptoms, and severe neurological complications such as paralysis. The neural spread of poliovirus can lead to permanent damage to the central nervous system, making it a significant public health concern.

✓ Correct Answer: C. Poliovirus