Hereditary orotic aciduria Type-I is due to deficiency of
Correct Answer: Orotate phosphoribosyl transferase
Description: The orotic aciduria is a consequence of the inability of severely damaged mitochondria to utilize carbamoyl phosphate, which then becomes available for cytosolic overproduction of orotic acid.Type-I orotic aciduria reflects a deficiency of both orotate phosphoribosyltransferase and orotidylate decarboxylaseThe rarer Type-II orotic aciduria is due to a deficiency only of orotidylate decarboxylaseRef: Harper 27e, page no:354
Category:
Biochemistry
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