Choose the false statement regarding Hepatitis G virus -a) Also called GB virusb) Blood born RNA virusc) Mostly infected with C virusd) Responds to Lamivudine

**Core Concept**
Hepatitis G virus (HGV), also known as GB virus C (GBV-C), is a member of the Flaviviridae family and is an RNA virus. It is primarily transmitted through blood transfusions and is often co-infected with other hepatitis viruses, including hepatitis C virus (HCV).

**Why the Correct Answer is Right**
The correct answer is **Option D:** Responds to Lamivudine. Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) used to treat hepatitis B virus (HBV) and HIV infection, but it is not effective against HGV/GBV-C. HGV/GBV-C does not respond to antiviral therapy with lamivudine or other NRTIs. The exact mechanism of HGV/GBV-C replication is not well understood, and no effective treatment is available.

**Why Each Wrong Option is Incorrect**
* **Option A:** Also called GB virus. This is true, as HGV is also known as GB virus C (GBV-C).
* **Option B:** Blood born RNA virus. This is true, as HGV is a blood-borne RNA virus.
* **Option C:** Mostly infected with C virus. This is true, as HGV is often co-infected with HCV.

**Clinical Pearl / High-Yield Fact**
HGV/GBV-C is often co-infected with other hepatitis viruses, including HCV, and can be transmitted through blood transfusions. However, it does not respond to antiviral therapy and its clinical significance is not well understood.

**Correct Answer:**
Correct Answer: D.