**Question:** Viral infection with haemolysis is seen in:

A. Hepatitis-B
B. Hepatitis-C
C. Prolong fever
D. Hepatitis-A

**Correct Answer:**

**Core Concept:** Viral haemolysis is a condition characterized by the destruction of red blood cells (RBCs) due to viral infection. In this case, we are focusing on viral infections causing haemolysis rather than non-infectious causes like drug reactions or autoimmune diseases.

**Why the Correct Answer is Right:**

Correct answer A (Hepatitis-B) refers to hepatitis B virus (HBV) infection, which may lead to acute or chronic liver disease. Hepatitis B can cause haemolysis due to liver dysfunction and impairment of RBC degradation (erythrophagocytosis) in the liver.

Answer B (Hepatitis-C) describes hepatitis C virus (HCV) infection. While HCV can lead to liver disease and haemolysis, it is less common compared to hepatitis B.

Answer D (Hepatitis-A) refers to hepatitis A virus (HAV) infection, which primarily affects the liver and can cause hepatitis but is generally less severe than HBV and HCV.

**Why Each Wrong Option is Incorrect:**

Wrong answer C (Prolong fever) is not a specific viral infection but rather a symptom associated with any prolonged febrile illness. It does not differentiate between the various viral infections mentioned in the question.

**Clinical Pearl:**

Hepatitis B and C are the primary viral causes of haemolysis due to their direct involvement in liver function and impaired RBC degradation. While hepatitis A can cause hepatitis, it is generally less severe than hepatitis B and C, and therefore less likely to cause haemolysis. The correct answers are A and B, while option D is less common.

Understanding the differentiation between these viral infections and their association with haemolysis is crucial, as it helps differentiate clinical presentations and guides appropriate management strategies.