**Core Concept:**
The mariners of active replicative phase of chronic hepatitis B are cellular proteins or enzymes that regulate and facilitate the DNA replication during the viral replication cycle. In this context, mariners refer to factors involved in the hepatitis B virus (HBV) replication cycle. HBV is a DNA virus, and its replication involves various cellular components.

**Why the Correct Answer is Right:**
Hepatitis B e-antigen (HBeAg) is correctly marked as an inhibitor of active replicative phase of chronic hepatitis B. HBeAg is produced by the virus during its replication cycle and plays a role in immune system evasion. It is secreted by infected hepatocytes and can be detected in the blood of HBV carriers.

**Why Each Wrong Option is Incorrect:**

A. HBeAg - As mentioned earlier, HBeAg is an important factor in the viral replication cycle and serves as an inhibitor of the active replicative phase of chronic hepatitis B.

B. Hepatitis B surface antigen (HBsAg) - Although HBsAg is also produced during the viral replication cycle, it is involved in the transmission of the virus and is not directly related to the active replicative phase.

C. Hepatitis B core antigen (HBcAg) - HBcAg is a core protein of the HBV genome and is involved in viral assembly and release. It is not specifically related to the active replicative phase of chronic hepatitis B.

D. Hepatitis B e-antibody (anti-HBe) - Anti-HBe is a neutralizing antibody against HBeAg and does not directly participate in the active replicative phase of chronic hepatitis B.

**Clinical Pearl / High-Yield Fact:**
The active replicative phase of chronic hepatitis B is crucial to understand as it helps in differentiating acute from chronic hepatitis B infection. A positive HBeAg (HBV replication) and a negative anti-HBe indicate an acute HBV infection. On the other hand, a positive HBsAg (HBV surface antigen), positive HBeAg, and negative HBe antibody suggest chronic hepatitis B infection.

**Correct Answer:** D (Hepatitis B e-antibody)

The correct answer is anti-HBe, which is a neutralizing antibody against HBeAg. It is produced by the host immune system in response to HBeAg presence. Anti-HBe does not directly participate in the active replicative phase of chronic hepatitis B infection. Instead, it is a marker of the immune response against HBV infection.