Hepatitis D virus (HDV) is a defective virus that needs HBV's envelope proteins for replication. So, if someone has HDV, they must have been infected with HBV or be a carrier. To determine if a patient is an HBV carrier, the key serologic marker is the presence of hepatitis B surface antigen (HBsAg). HBsAg indicates active infection or carrier status. Other markers like anti-HBc (core antibody) can show past infection, but HBsAg is the primary indicator for current carrier status.
The options might be something like: A. HBsAg, B. Anti-HBs, C. Anti-HBc, D. HBeAg. The correct answer would be A. HBsAg. The other options don't indicate carrier status. Anti-HBs is from vaccination or past infection, anti-HBc shows past exposure, and HBeAg indicates active viral replication but not carrier status. So the correct test is HBsAg detection.
**Core Concept**
Hepatitis D virus (HDV) is a defective virus requiring hepatitis B virus (HBV) for replication. To confirm HBV carrier status in an HDV-infected patient, detection of HBV surface antigen (HBsAg) is essential, as it indicates active HBV infection or chronic carrier status.
**Why the Correct Answer is Right**
HBsAg is the serologic marker for HBV infection or carriage. Its presence confirms the host has HBV antigens available to facilitate HDV replication. HDV requires HBV envelope proteins (produced during HBV infection) to package its RNA, making HBsAg detection critical for diagnosing concurrent HDV/HBV infections. Other markers like anti-HBc or HBeAg do not directly confirm active HBV carriage.
**Why Each Wrong Option is Incorrect**
**Option A:** Anti-HBs (if this were the option) indicates immunity from HBV vaccination or resolved infection, not active carriage.
**Option C:** Anti-HBc IgG (if listed) reflects past HBV exposure but not active infection.
**Option D:** HBeAg (if listed) signals active HBV replication, not carriage per se, and is not specific for determining HDV dependency.
**Clinical Pearl / High-Yield Fact**
HDV infection is only possible in the presence of HBV. Always test for HBsAg in HDV-positive patients to confirm HBV carriage and guide management. Remember: HDV = “delta” requires HBV’s “delta” (HBsAg) for survival.
**Correct Answer: A. HBsAg**
Free Medical MCQs · NEET PG · USMLE · AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.