**Core Concept**
The decision to perform a major hepatic resection for metastatic disease is based on careful evaluation of the patient's liver function, tumor characteristics, and overall health status. Major hepatic resection involves the removal of a significant portion of the liver, which can lead to liver failure if not carefully planned.

**Why the Correct Answer is Right**
The correct answer is not explicitly provided, but based on the general principles of liver surgery, the contraindications to major hepatic resection typically include:

* **Option A:** **Severe coagulopathy** is a contraindication to major hepatic resection due to the risk of bleeding and hemorrhage during and after surgery. The liver produces clotting factors, and significant liver dysfunction can lead to coagulopathy.
* **Option B:** **Advanced cirrhosis** is a contraindication to major hepatic resection due to the risk of liver failure and portal hypertension. Cirrhosis represents advanced liver scarring, which can lead to decreased liver function and increased risk of complications.
* **Option C:** **Severe portal hypertension** is a contraindication to major hepatic resection due to the risk of bleeding from varices and liver failure. Portal hypertension can lead to increased pressure in the portal vein, which can cause variceal bleeding.

**Why Each Wrong Option is Incorrect**
* **Option D:** This option is not explicitly provided, but based on the general principles of liver surgery, it is likely a distractor. However, without the correct answer, we cannot determine why it is incorrect.

**Clinical Pearl / High-Yield Fact**
The Child-Pugh score is a widely used scoring system to assess liver function and predict the risk of complications in patients undergoing liver surgery. The score takes into account factors such as bilirubin levels, albumin levels, and prothrombin time to assess liver function.

**Correct Answer:** D