**Core Concept**
Heparin is a glycosaminoglycan anticoagulant that works by enhancing the activity of antithrombin III, leading to inhibition of thrombin and factor Xa. It is widely used in cardiac surgery to prevent thrombus formation during and after procedures.
**Why the Correct Answer is Right**
Option A is incorrect because heparin is not a weak acid; it is a polysaccharide with no significant acidic properties. The statement "weakest acid found in living things" refers to **acetic acid**, not heparin. Heparin does not exhibit acid-base behavior in the way described. The other options are pharmacologically accurate: B is true as most heparin is derived from pig intestine; C correctly describes its mechanism via antithrombin activation; D is true as heparin can induce immune-mediated thrombocytopenia (heparin-induced thrombocytopenia, HIT).
**Why Each Wrong Option is Incorrect**
Option B: Incorrectly stated β while pig intestinal sources were historically used, **modern heparin is primarily derived from porcine intestinal mucosa**, so this statement is factually correct and thus not the exception.
Option C: Incorrectly stated β heparin **does act via antithrombin activation**, which is a well-established mechanism.
Option D: Incorrectly stated β heparin **can cause thrombocytopenia**, especially in HIT, a known adverse effect.
**Clinical Pearl / High-Yield Fact**
Heparin-induced thrombocytopenia (HIT) is a serious, potentially life-threatening complication that requires immediate recognition and discontinuation of heparin. Always consider HIT in patients with unexplained thrombocytopenia during anticoagulation.
β Correct Answer: A. Weakest acid found in living things
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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