Heparin inhibits Xa by

A. Blocking vitamin K mediated activation of Xa

B. Activating Antithrombin III

C. Direct breakdown of Xa

D. Blocking P2 Y12 receptor of ADP

Correct Answer: Activating Antithrombin III

Description: Heparin contains pentasaccharide unit that activates Antithrombin III & inhibits factor Xa (Thus it is a indirect thrombin inhibitor). Unfractionised heparin also contains a heteropolysaccharide unit that inhibits factor II a. LMWH lacks this heteropolysacchoride unit and therefore inhibitors factor Xa only.

Category: Pharmacology

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