**Question:** Hemosiderosis of liver, pigment deposited is

A. Ferritin
B. Siderophages
C. Bilirubin
D. Albedo

**Core Concept:** Hemosiderosis is a condition characterized by the accumulation of iron in tissues, typically due to chronic hemolysis or hemosiderin-laden macrophages (siderophages) in the liver. Hemosiderin is a form of iron and can be deposited in tissues as a result of iron overload or hemolysis.

**Why the Correct Answer is Right:** In hemosiderosis of liver, the deposited pigment is hemosiderin, which is a form of iron. Hemosiderin is primarily produced by the phagocytosis of hemosiderin-laden macrophages (siderophages) in the liver, leading to iron accumulation and deposition in the liver tissue.

**Why Each Wrong Option is Incorrect:**

A. Ferritin: Ferritin is an iron storage protein found in cells rather than a pigment deposited in tissues like hemosiderin.

B. Siderophages: While siderophages are iron-laden macrophages involved in hemosiderin uptake, the deposited pigment in hemosiderosis is hemosiderin, not siderophages themselves.

C. Bilirubin: Bilirubin is a waste product of heme catabolism and not related to iron deposition in tissues.

D. Albedo: Albedo refers to a lack of pigmentation or whitish appearance and is unrelated to the pigment deposited in hemosiderosis.

**Clinical Pearl:** Hemosiderosis can result from chronic hemolysis, blood transfusions, or inherited disorders like hemochromatosis (iron overload) or thalassemias, leading to tissue iron deposition and potential organ damage. Adequate management includes identifying the underlying cause, controlling hemolysis, and managing iron overload with chelation therapy when necessary.