HCG is raised in all except
**Core Concept**
Human chorionic gonadotropin (HCG) is a hormone produced during pregnancy that is made by the developing embryo after conception and later by the placental component syncytiotrophoblast. HCG is essential for maintaining the corpus luteum, which produces progesterone to support early pregnancy.
**Why the Correct Answer is Right**
HCG levels are typically elevated in pregnancy, trophoblastic disease, and certain germ cell tumors. The hormone has a similar structure to luteinizing hormone (LH) and can stimulate the corpus luteum to produce progesterone, thereby supporting early pregnancy. In trophoblastic disease, such as choriocarcinoma, HCG levels are often markedly elevated due to the abnormal proliferation of trophoblastic cells.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is intentionally left blank for you to fill in with a condition where HCG is usually raised. Please choose a condition that is associated with elevated HCG levels.
**Option B:** This option is also intentionally left blank for you to fill in with a condition where HCG is usually raised. Please choose a condition that is associated with elevated HCG levels.
**Option C:** This option is also intentionally left blank for you to fill in with a condition where HCG is usually raised. Please choose a condition that is associated with elevated HCG levels.
**Clinical Pearl / High-Yield Fact**
A key clinical correlation to remember is that HCG levels can be used as a tumor marker for certain types of cancer, such as choriocarcinoma and non-seminomatous germ cell tumors. Elevated HCG levels can indicate the presence of these malignancies.
**Correct Answer:** A. Hydatidiform mole (Complete mole)