**Question:** Hazard of chorionic villous biopsy is:

A. Increased risk of infection
B. Increased risk of hemorrhage
C. Increased risk of fetal loss
D. Increased risk of chromosomal abnormalities

**Core Concept:**

Chorionic villous biopsy is a diagnostic procedure performed on the placenta in early pregnancy to evaluate abnormalities or abnormalities suspected based on maternal symptoms and ultrasound findings. It involves the removal of chorionic villi, which are finger-like projections of the placenta that connect the fetus to the uterine wall. This procedure is essential for diagnosing various fetal conditions, such as aneuploidy, genetic disorders, and infections.

**Why the Correct Answer is Right:**

The correct answer, **D.** Increased risk of chromosomal abnormalities, highlights a potential hazard of chorionic villous biopsy. The procedure can cause genetic material to be introduced into the fetal bloodstream, increasing the risk of chromosomal abnormalities or genetic disorders being transmitted to the fetus. This risk is significant because genetic abnormalities can lead to severe health complications and life-altering outcomes for the fetus.

**Why Each Wrong Option is Incorrect:**

A. **Increased risk of infection (Option A)** is incorrect because chorionic villous biopsy is typically performed under sterile conditions to minimize infection risk. The procedure follows strict aseptic protocols, and the samples are sent to a laboratory for culture and sensitivity testing to identify any potential pathogens.

B. **Increased risk of hemorrhage (Option B)** is incorrect because the procedure is generally safe, and proper surgical techniques, including appropriate suturing and hemostasis, are employed to prevent excessive bleeding. Medical professionals ensure that the procedure is performed correctly and promptly manage any minor bleeding complications that may arise.

C. **Increased risk of fetal loss (Option C)** is incorrect because, when performed correctly, chorionic villous biopsy carries a minimal risk of causing fetal loss. However, if the procedure is performed at an inappropriate gestational age or the procedure is not done correctly, the risk of fetal loss may increase.

**Clinical Pearl:**

The correct answer (D) highlights the importance of understanding the potential risks associated with invasive fetal testing procedures. It is crucial for healthcare providers to follow strict guidelines and guidelines to minimize risks while performing these procedures. By doing so, they can optimize the benefits of these tests while minimizing the associated risks, including the risk of chromosomal abnormalities and genetic disorders. Additionally, it is crucial for healthcare professionals to consider gestational age and procedure technique when planning and performing these procedures to minimize risks such as fetal loss.