Hassall’s corpuscles are seen in:
**Core Concept**
Hassall's corpuscles are a type of concentric lamellated body found in the thymus, playing a crucial role in the maturation and selection of T-lymphocytes. They are composed of tightly packed, concentric layers of epithelial cells, which eventually undergo calcification and form a characteristic dense, eosinophilic structure.
**Why the Correct Answer is Right**
Hassall's corpuscles are formed in the medulla of the thymus, where T-lymphocytes undergo selection and maturation. The concentric lamellations of Hassall's corpuscles are thought to be involved in the process of T-cell selection and apoptosis. As T-lymphocytes mature, they migrate towards the medulla, where they come into contact with Hassall's corpuscles, which may play a role in their selection and elimination of autoreactive cells.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Hassall's corpuscles are not found in the spleen, which is primarily involved in filtering the blood and storing red blood cells.
**Option B:** This option is incorrect because the adrenal cortex is not associated with Hassall's corpuscles, which are specific to the thymus.
**Option C:** This option is incorrect because the lymph nodes do not have Hassall's corpuscles, which are a unique feature of the thymus.
**Clinical Pearl / High-Yield Fact**
Hassall's corpuscles are a key histological feature of the thymus, and their presence is often used to confirm the diagnosis of thymic tissue in histopathological samples.
**Correct Answer: C. Thymus. Thymus**