A female patient presents with patchy hair loss with normal looking skin on scalp. Diagnosis is?
**Core Concept**
Patchy hair loss with normal looking skin on the scalp is a classic presentation of alopecia areata, an autoimmune disease characterized by the body's immune system attacking hair follicles, leading to hair loss.
**Why the Correct Answer is Right**
Alopecia areata occurs when the immune system mistakenly identifies hair follicles as foreign and mounts an attack against them, resulting in hair loss. This process is mediated by T-lymphocytes and other immune cells that target the hair follicles, leading to inflammation and hair loss. The hair follicles themselves remain intact, which is why the skin appears normal.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the presentation of alopecia areata. Alopecia areata typically presents with patchy hair loss, not diffuse hair loss.
**Option B:** This option is incorrect because it is more characteristic of telogen effluvium, a condition that presents with diffuse hair loss, not patchy hair loss.
**Option C:** This option is incorrect because it is more characteristic of androgenetic alopecia, also known as male/female pattern baldness, which typically presents with thinning of hair on the scalp, not patchy hair loss.
**Clinical Pearl / High-Yield Fact**
Alopecia areata can affect any age group, including children, and can be associated with other autoimmune diseases such as thyroid disease and vitiligo.
**Correct Answer:** C. Androgenetic alopecia is the most common cause of hair loss in women, but it typically presents with thinning of hair on the scalp, not patchy hair loss.