Haemaccel contains ?
So, colloids work by exerting oncotic pressure to keep fluid in the vascular space. Common colloids include albumin, hydroxyethyl starch (HES), dextran, and gelatin. Haemaccel is a brand name, so I need to figure out which of these it corresponds to.
Wait, I think Haemaccel is a type of dextran. Dextran is a polysaccharide made from sucrose by the action of Leuconostoc bacteria. Different molecular weights of dextran have different uses. Low molecular weight dextran might be used for anticoagulant properties, while higher molecular weight ones are used as plasma expanders.
Haemaccel specifically, I believe, is a 6% dextran 70 solution. The 70 refers to the average molecular weight in thousands. So the active ingredient is dextran 70. Other colloids like HES have different structures. For example, HES is a modified starch, whereas dextran is a bacterial product.
Now, looking at the options, even though they aren't listed here, the correct answer would be dextran. The other options might be things like albumin, gelatin, or HES. For example, if an option says hydroxyethyl starch, that's incorrect because that's a different colloid. Similarly, gelatin-based solutions like Gelofusine are different from dextran.
Clinical pearls: Remember that dextran solutions can cause anaphylactic reactions, especially in patients with a history of atopy. Also, they can interfere with crossmatching for blood transfusions. High molecular weight dextran is used for volume expansion, while lower molecular weight is used for improving microcirculation and preventing clotting.
**Core Concept**
Haemaccel is a plasma volume expander containing dextran, a polysaccharide derived from bacterial fermentation. It functions by increasing intravascular oncotic pressure to treat hypovolemia.
**Why the Correct Answer is Right**
Haemaccel is a 6% solution of dextran 70 (average molecular weight 70,000 Da), which acts as a colloid to expand intravascular volume. Dextran 70 is a high-molecular-weight polymer that remains in the vascular space longer than smaller dextrans, making it effective for volume resuscitation. It works by increasing oncotic pressure, drawing interstitial fluid into the vasculature.
**Why Each Wrong Option is Incorrect**
**Option A:** If it lists "Hydroxyethyl starch," this is incorrect. Hydroxyethyl starch (e.g., HES 200/0.5) is a different colloid, not dextran.
**Option B:** If it lists "Albumin," this is incorrect. Albumin is a natural colloid but not the component of Haemaccel.
**Option C:** If it lists "Gelatin," this is incorrect. Gelatin-based solutions (e.g., Gel