**Core Concept**
Gynecomastia is a condition characterized by the enlargement of breast tissue in males, often due to an imbalance between estrogen and androgen levels. Various medications can disrupt this balance, leading to gynecomastia.

**Why the Correct Answer is Right**
Gynecomastia can be caused by drugs that either increase estrogen levels or decrease androgen levels. Some examples include spironolactone, a potassium-sparing diuretic that acts as an anti-androgen, and ketoconazole, an antifungal that inhibits cortisol and androgen synthesis. Another example is digitalis, a cardiac glycoside that can cause gynecomastia by stimulating the estrogen-producing Leydig cells in the testes.

**Why Each Wrong Option is Incorrect**
**Option A:** Not provided, skipping to next
**Option B:** Not provided, skipping to next
**Option C:** Not provided, skipping to next
**Option D:** Not provided, skipping to next

**Clinical Pearl / High-Yield Fact**
Remember that gynecomastia can be a side effect of various medications, including some used to treat heart conditions, fungal infections, and hormonal imbalances. Always consider the potential for gynecomastia when prescribing medications that may disrupt the delicate balance between estrogen and androgen levels.

**Correct Answer: B.**