Guardian of the genes is?
Correct Answer: p53
Description: Ans. is 'b' i.e., p53 * p53 is a tumor suppressor gene. p53 gene is located on chromosome 17. p53 acts as molecular policeman that prevents the propagation of genetically damage cell.* p-53 is the most common target for genetic alteration in human tumors; A little over 50% of human tumors contain mutation in this gene.(Note - Amongst oncogene RAS is involved most commonly)* The major functional activities of the p53 protein are cell cycle arrest and initiation of apoptosis in response to DNA damage.
Category:
Pathology
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