Growth factor oncogene is –
Correct Answer: sis
Description: Sis oncogene is a growth factor.
Myc, jun and fos oncogenes are nuclear regulatory proteins
Following information have been added in 8th/ e of Robbin's
miRNA and cancer
It has already been explained in genetics that miRNA is a gene-silencing RNA, i.e. it inhibits gene expression at post-transcription level.
So, miRNA can be involved in tumorigenesis in two ways :
Reduced activity of miRNA that inhibits translation of an oncogene will result in excess of oncoprotein and tumorigenesis. For example, mRNA inhibits expression of anti-apoptotic gene Bcl 2. Reduced activity of this miRNA results in over-expression of Bcl-2 which inhibits apoptosis and results in leukaemia and lymphoma. Similarly, miRNA mediated upregulation of Ras and Myc oncogenes has been detected in lung tumor and B-cell leukemia, respectively.
On the other hand, overactivity of miRNA that targets a tumor suppression gene will result in inhibition of expression of tumor suppressor gene and tumorigenesis.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now