Greater risk of carcinoma of stomach is associated with-
## **Core Concept**
The question tests the association between various conditions and the risk of developing gastric carcinoma. Gastric carcinoma, also known as stomach cancer, has several risk factors including genetic, environmental, and infectious factors.
## **Why the Correct Answer is Right**
The correct answer, **pernicious anaemia**, is associated with a greater risk of gastric carcinoma. Pernicious anaemia is an autoimmune condition that leads to vitamin B12 deficiency due to the lack of intrinsic factor. This condition is known to increase the risk of gastric cancer, possibly due to chronic atrophic gastritis which can progress to intestinal metaplasia and eventually to gastric carcinoma.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because while certain conditions may increase the risk of gastric carcinoma, the specific association with pernicious anaemia makes option B the correct choice.
- **Option C:** This option does not directly relate to a well-established risk factor for gastric carcinoma comparable to pernicious anaemia.
- **Option D:** Similarly, this option does not represent a recognized risk factor for gastric carcinoma.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that patients with pernicious anaemia have an increased risk of developing gastric carcinoma. This association underscores the importance of long-term follow-up and surveillance in patients with pernicious anaemia.
## **Correct Answer:** B. pernicious anaemia