### Core Concept
Neuroblastoma is a type of pediatric cancer that originates from the sympathetic nervous system. Prognostic factors in neuroblastoma are used to predict the likelihood of disease recurrence or progression, and guide treatment decisions. Good prognostic factors indicate a better outcome.

### Why the Correct Answer is Right
Good prognostic factors for neuroblastoma include:

* **Age at diagnosis**: Infants diagnosed at a younger age tend to have a better prognosis.
* **Stage at diagnosis**: Patients with stage 1 or 2 neuroblastoma have a better prognosis compared to those with advanced disease.
* **Biological characteristics**: Neuroblastomas with a **gain of 17q** or **absence of MYCN amplification** are associated with a better prognosis.

### Why Each Wrong Option is Incorrect
**Option A:** Age at diagnosis is actually a good prognostic factor, as infants diagnosed at a younger age tend to have a better outcome.

**Option B:** Stage at diagnosis is also a good prognostic factor, as patients with stage 1 or 2 neuroblastoma have a better prognosis.

**Option C:** Biological characteristics such as gain of 17q or absence of MYCN amplification are good prognostic factors.

### Clinical Pearl / High-Yield Fact
It's essential to remember that MYCN amplification is a high-risk feature in neuroblastoma, and patients with MYCN-amplified tumors tend to have a poorer prognosis.

### Correct Answer: D