Glycolytic enzymes(s) inhibited by Fluoride : (PGI Dec 2008)
Correct Answer: Enolase
Description: Ans : C (Enolase) Enolase is inhibited by fluorideInhibitors of Glycolytic Enzyme -Shinde 7th/308-310FluorideFluoride inhibits the enzyme 'enolaseQNaFQ is used along with K-oxalate for collection of blood. If K-oxalate is used alone, then in vitro, glycolysis will reduce the glucose value in the sampleOther Functions of fluoride : It also acts as anticoagulant & act as an antisepticArseniteIt competes with inorganic Pi in the reaction of conversion of glyceraldehyde -3- P to 1,3- biphospho-glycerate & divert reaction in the manner in which no ATP is produced.D-gIyceraJdehyde-3-P + NAD' + PiGlycerai dehyde -3-P ---------dehydrogenase1, 3-biphosphaogIycerate + NADH + H+Iodoacetate & lodoacetamide# They bind irreversibly with the enzyme glyceraldehyde -3-P dehydrogenase & inhibit glycolysis.Bromohydroxyacetone - P# It inhibit enzyme phosphotriose isomeraseDihvd roxyacetone-PiPhosphotrioseiosmeraseD -glyceraldehyde-3-PAlso knowEnolase catalyse following reaction2 -phosphoglycerateenolase--------Mg2+ or Mn2+phosphenolpyruvateInhibitor in TCA cycleFluoroacetate inhibit aconitaseArseniteQ inhibit the conversion of a-ketoglutarate to succinyl-CoA catalysed by enzyme a-ketoglutarate dehydrogenase complexQMalonateQ inhibit succinate dehydrogenaseQ competitively.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now