Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?

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Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm

Answer

The thermodynamics does not or such a reaction to occur

Answer

Glycogenesis and glycogenolysis are tightly regulated such that enzymes of only one of those is present at a time.

Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?

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