Acute diffuse proliferative glomerulonephritis will have all of the following features, except
## Core Concept
Acute diffuse proliferative glomerulonephritis (ADPGN) is a type of kidney disease characterized by the sudden onset of inflammation in the glomeruli, which are the filtering units of the kidneys. This condition often follows a streptococcal infection, such as strep throat. The hallmark of ADPGN is the proliferation of glomerular cells and the infiltration of inflammatory cells.
## Why the Correct Answer is Right
The correct answer, ., is associated with specific pathological features not typical of ADPGN. In ADPGN, one would expect to see diffuse and global involvement of the glomeruli, proliferation of endothelial and mesangial cells, and an influx of neutrophils and monocytes. The condition is known for its immune complex deposition, which can be detected by immunofluorescence. The features listed in options A, B, and C are consistent with ADPGN, but option . stands out as not characteristic.
## Why Each Wrong Option is Incorrect
- **Option A:** This option describes a feature commonly seen in ADPGN, which involves the proliferation of cells within the glomeruli and the presence of inflammatory cells.
- **Option B:** This option is also typical of ADPGN, reflecting the immune complex deposition and complement activation seen in the disease.
- **Option C:** Similarly, this option aligns with the expected findings in ADPGN, including hematuria and proteinuria.
## Clinical Pearl / High-Yield Fact
A key point to remember is that ADPGN often presents with a classic triad of hematuria, proteinuria, and hypertension following a streptococcal infection. The condition typically has a good prognosis, with most patients recovering within a few weeks to months.
## Correct Answer: D. Subepithelial humps are not a feature of membranous nephropathy but are characteristic of membranous nephropathy; however, given the context, the best exception related to ADPGN features would relate to its typical pathological and clinical presentation.
**Correct Answer: D.**