**Core Concept**
Glipizide and chlorpropamide are both second-generation sulfonylureas, a class of drugs used to treat type 2 diabetes mellitus. These medications work by stimulating insulin release from the pancreatic beta cells. However, they have distinct differences in their pharmacological properties.

**Why the Correct Answer is Right**
Glipizide differs from chlorpropamide in its onset and duration of action. Glipizide has a shorter onset of action (1-2 hours) and a shorter duration of action (12-18 hours), whereas chlorpropamide has a longer onset of action (2-4 hours) and a longer duration of action (60-72 hours). This difference in pharmacokinetics is due to the varying degrees of protein binding and first-pass metabolism of these sulfonylureas. Glipizide has a higher lipid solubility and is more extensively metabolized by the liver, resulting in a faster onset and shorter duration of action.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option does not provide any information about the differences between glipizide and chlorpropamide.
* **Option B:** This option is incorrect because glipizide does not have a longer duration of action compared to chlorpropamide.
* **Option C:** This option is incorrect because glipizide does not have a lower potency compared to chlorpropamide.

**Clinical Pearl / High-Yield Fact**
When choosing between glipizide and chlorpropamide, clinicians should consider the patient's renal function, as chlorpropamide is primarily excreted by the kidneys, whereas glipizide is metabolized by the liver. This can help guide the selection of the most appropriate sulfonylurea for a particular patient.

**Correct Answer:** D.