Glanzman’s thromboasthenia is characterized by defective –
Correct Answer: Gp IIB/IIIA
Description: Ans is 'a' Gp IIB/IIIA Glanzman's thrombastheniao It is an autosomal recessive disorder due to deficiency/dysfunction of glycoprotein Ilb-IIla (Gp Ilb/IIIa). Thus there is defective platelet aggregation.o Platelet aggregation is normal to ristocetin(ln constant to Bernard soulier syndrome) but no aggregation occurs in response to standard agonists (collagen, A DP, thrombin).o Other differentiating features include normal platelet count and morphologyo BT is prolonged. vWF is normal.o The disease manifests at birth with increased bleeding from umbilical cord stump.
Category:
Pathology
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