## **Core Concept**
Glanders disease, also known as Farcy's disease or Malleus, is a bacterial infection caused by *Burkholderia mallei*. It primarily affects the skin, lungs, and mucous membranes. The disease is more common in individuals who come into contact with infected animals, particularly horses.

## **Why the Correct Answer is Right**
The correct answer, *Burkholderia mallei*, is the causative agent of glanders. This bacterium is a gram-negative, rod-shaped organism that can lead to a range of clinical manifestations, from acute septicemia to chronic infection. The infection typically occurs through skin contact with infected animals or contaminated materials.

## **Why Each Wrong Option is Incorrect**
* **Option A:** *Burkholderia cepacia* is a bacterium that can cause infections, particularly in people with compromised immune systems or cystic fibrosis, but it is not the cause of glanders.
* **Option B:** *Pseudomonas aeruginosa* is a common pathogen in various infections, especially in immunocompromised patients and those with cystic fibrosis, but it does not cause glanders.
* **Option D:** *Streptococcus pneumoniae* is a major cause of community-acquired pneumonia and other infections, but it is not associated with glanders.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that glanders is a zoonotic disease, meaning it can be transmitted from animals to humans. Individuals at high risk include veterinarians, horse handlers, and laboratory workers who may come into contact with infected animals or contaminated samples.

## **Correct Answer:** C. *Burkholderia mallei*.