“Face of giant panda” sign on MRI brain is seen in:
**Core Concept**
The "face of giant panda" sign on MRI brain is a radiological term used to describe a specific pattern of brain injury. It is associated with a particular type of stroke or cerebral vasculature anomaly. This sign is characterized by a distinct pattern of hyperintensity on MRI, resembling the markings on a giant panda's face.
**Why the Correct Answer is Right**
The "face of giant panda" sign is typically seen in cases of giant cell arteritis (GCA), a form of vasculitis that affects the medium and large arteries, including those supplying the head. The sign is thought to result from the inflammation of the internal carotid artery, which can lead to ischemia and infarction of the anterior cerebral circulation. The hyperintensity on MRI is due to the presence of giant cells, which are characteristic of GCA.
**Why Each Wrong Option is Incorrect**
**Option A:** Not relevant to the "face of giant panda" sign.
**Option B:** This option is incorrect because the "face of giant panda" sign is not typically associated with moyamoya disease, which is a different type of cerebral vasculopathy.
**Option C:** This option is incorrect because the "face of giant panda" sign is not a feature of hypertensive intracerebral hemorrhage.
**Option D:** This option is incorrect because the "face of giant panda" sign is not typically associated with cerebral venous sinus thrombosis.
**Clinical Pearl / High-Yield Fact**
The "face of giant panda" sign is a classic radiological finding in GCA and should prompt investigation for this condition, particularly in patients presenting with headache, visual disturbances, and jaw claudication.
**Correct Answer:** C.